Levon M Khachigian Selected Research

Catalytic DNA (Deoxyribozyme)

1/2019	Deoxyribozymes as Catalytic Nanotherapeutic Agents.
1/2018	Melanoma protective antitumor immunity activated by catalytic DNA.
10/2013	Inhibition of vein graft stenosis with a c-jun targeting DNAzyme in a cationic liposomal formulation containing 1,2-dioleoyl-3-trimethylammonium propane (DOTAP)/1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE).
7/2013	Selective inhibition of the master regulator transcription factor Egr-1 with catalytic oligonucleotides reduces myocardial injury and improves left ventricular systolic function in a preclinical model of myocardial infarction.
6/2012	DNAzyme targeting c-jun suppresses skin cancer growth.
6/2012	Intracoronary delivery of DNAzymes targeting human EGR-1 reduces infarct size following myocardial ischaemia reperfusion.
6/2012	Destroying c-jun Messenger: new insights into biological mechanisms of DNAzyme function.
2/2010	c-Jun regulates shear- and injury-inducible Egr-1 expression, vein graft stenosis after autologous end-to-side transplantation in rabbits, and intimal hyperplasia in human saphenous veins.
11/2009	c-Jun DNAzymes inhibit myocardial inflammation, ROS generation, infarct size, and improve cardiac function after ischemia-reperfusion injury.
9/2008	Biocompatible chitosan-DNAzyme nanoparticle exhibits enhanced biological activity.

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Levon M Khachigian Research Topics

Disease

23	Neoplasms (Cancer) 12/2021 - 01/2002
11	Neointima 01/2021 - 01/2002
11	Atherosclerosis 09/2012 - 03/2004
6	Inflammation (Inflammations) 01/2020 - 12/2003
6	Hyperplasia 12/2018 - 05/2003
5	Wounds and Injuries (Trauma) 01/2020 - 08/2006
5	Vascular System Injuries 10/2019 - 08/2008
5	Neoplasm Metastasis (Metastasis) 10/2019 - 10/2005
4	Reperfusion Injury 12/2020 - 03/2004
4	Melanoma (Melanoma, Malignant) 10/2019 - 05/2004
4	Myocardial Infarction 07/2013 - 11/2006
4	Osteosarcoma (Osteogenic Sarcoma) 09/2008 - 07/2008
3	Thrombosis (Thrombus) 01/2021 - 11/2006
3	Skin Neoplasms (Skin Cancer) 01/2020 - 06/2012
3	Myocardial Ischemia (Ischemic Heart Diseases) 01/2019 - 11/2009
3	Pathologic Constriction (Stenosis) 12/2018 - 02/2010
3	Fibrosis (Cirrhosis) 01/2014 - 09/2004
3	Breast Neoplasms (Breast Cancer) 09/2013 - 08/2003
3	Infarction (Infarctions) 07/2013 - 11/2009
3	Carcinogenesis 04/2008 - 09/2003
2	Arthritis (Polyarthritis) 01/2021 - 01/2006
2	Hypoxia (Hypoxemia) 01/2018 - 06/2010
2	Coronary Artery Disease (Coronary Atherosclerosis) 10/2016 - 06/2011
2	Basal Cell Carcinoma (Rodent Ulcer) 10/2013 - 05/2013
2	Squamous Cell Carcinoma (Epidermoid Carcinoma) 06/2012 - 05/2009
2	Retinal Neovascularization 01/2012 - 07/2010
2	Thrombocytopenia (Thrombopenia) 10/2010 - 09/2010
2	Rheumatoid Arthritis 07/2006 - 01/2006
1	Osteitis 01/2021
1	Sepsis (Septicemia) 12/2020
1	Venous Thrombosis (Deep-Vein Thrombosis) 12/2020
1	Necrosis 11/2020
1	Pancreatic Neoplasms (Pancreatic Cancer) 04/2018
1	ST Elevation Myocardial Infarction 01/2018
1	Carotid Artery Injuries 06/2016

Drug/Important Bio-Agent (IBA)

21	Catalytic DNA (Deoxyribozyme)IBA 01/2019 - 06/2002
12	Transcription Factors (Transcription Factor)IBA 01/2021 - 08/2003
8	Messenger RNA (mRNA)IBA 06/2012 - 01/2004
7	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 11/2020 - 01/2002
6	LigandsIBA 10/2019 - 09/2004
6	Proteins (Proteins, Gene)FDA Link 05/2009 - 09/2003
5	Fibroblast Growth Factor 2 (Basic Fibroblast Growth Factor)IBA 11/2020 - 05/2003
5	MicroRNAs (MicroRNA)IBA 10/2019 - 09/2013
4	Small Interfering RNA (siRNA)IBA 02/2013 - 08/2006
4	Platelet-Derived Growth FactorIBA 10/2010 - 09/2004
3	CytokinesIBA 01/2021 - 01/2014
3	Retinaldehyde (Retinal)IBA 01/2020 - 07/2010
3	AntibodiesIBA 01/2018 - 09/2010
3	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 10/2016 - 05/2004
3	OligonucleotidesIBA 07/2013 - 09/2003
2	flubendazoleIBA 12/2021 - 10/2019
2	CollagenIBA 01/2021 - 01/2006
2	Matrix Metalloproteinases (MMPs)IBA 11/2020 - 01/2012
2	AnthelminticsIBA 01/2020 - 10/2019
2	matrigelIBA 01/2020 - 08/2003
2	Heme Oxygenase-1IBA 01/2018 - 12/2010
2	Caspase 3 (Caspase-3)IBA 01/2018 - 01/2018
2	Cyclin D1IBA 01/2018 - 05/2012
2	RNA (Ribonucleic Acid)IBA 04/2015 - 09/2013
2	Dz13 DNAzymeIBA 10/2013 - 05/2013
2	Thromboplastin (Tissue Factor)IBA 07/2013 - 07/2004
2	Proteoglycans (Proteoglycan)IBA 09/2012 - 09/2010
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 04/2010 - 03/2008
2	Protein CIBA 11/2009 - 07/2006
2	NF-kappa B (NF-kB)IBA 05/2009 - 03/2008
2	ChitosanIBA 09/2008 - 07/2008
2	MitogensIBA 04/2008 - 09/2004
2	Chemotactic FactorsIBA 04/2008 - 09/2004
2	EndotoxinsIBA 07/2006 - 01/2006
2	heparanaseIBA 10/2005 - 12/2003
1	Programmed Cell Death 1 ReceptorIBA 12/2021
1	Histones (Histone)IBA 12/2020
1	Vascular Cell Adhesion Molecule-1 (Vascular Cell Adhesion Molecule 1)IBA 01/2020
1	Antihypertensive Agents (Antihypertensives)IBA 01/2020
1	Paclitaxel (Taxol)FDA LinkGeneric 10/2019
1	Nucleic AcidsIBA 01/2019
1	Vitamin D FDA LinkGeneric 01/2018
1	Long Noncoding RNAIBA 01/2018
1	Antineoplastic Agents (Antineoplastics)IBA 01/2018
1	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 01/2018
1	Superoxides (Superoxide)IBA 01/2018
1	Cytochromes c (Cytochrome c)IBA 01/2018
1	cyclic arginine-glycine-aspartic acid peptideIBA 10/2016
1	Vascular Endothelial Growth Factor DIBA 10/2016
1	NG-Nitroarginine Methyl Ester (L-NAME)IBA 10/2016
1	Estrogen ReceptorsIBA 04/2015
1	Epidermal Growth Factor (EGF)IBA 01/2014
1	platelet-derived growth factor C (PDGF-C)IBA 01/2014
1	Bleomycin (Blenoxane)FDA LinkGeneric 01/2014
1	Silicon Dioxide (Silica)FDA LinkGeneric 01/2014
1	phosphorylethanolamine (phosphoethanolamine)IBA 10/2013
1	1,2- dioleoyloxy- 3- (trimethylammonium)propaneIBA 10/2013

Therapy/Procedure

10	Therapeutics 12/2021 - 11/2006
5	Stents 01/2021 - 01/2002
5	Percutaneous Coronary Intervention 10/2019 - 04/2007
3	Transplantation 12/2018 - 02/2010
2	Immunotherapy 10/2019 - 02/2013
1	Drug-Eluting Stents 01/2021
1	Lasers (Laser) 01/2020
1	Withholding Treatment 01/2018